Sphingolipid Polar Heads: Hydrogen Bonding and Hydration

Maria (primary)
Chris Lorenz (secondary)
King's College London


Sphingolipid behaviour is critical in cell regulation and signaling, and it is believed to depend on interactions within and between sphingolipids’ polar heads, and with water. However, there are virtually no investigations of the interactions established by sphingolipids with atomic resolution. This project aims to elucidate these interactions by using a combination of synthetic, spectroscopic and molecular modelling methods.


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2 D. Loru, I. Peña, J.L. Alonso, M. E. Sanz, “Intramolecular interactions in the polar headgroup of sphingosine: serinol”, Chem.Comm., 47, 6216 (2016).
3 D. Loru et al, “Conformational Flexibility of Limonene Oxide Studied By Microwave Spectroscopy” ChemPhysChem, 18, 274 (2017), cover.
4 R. J. Gillams, C. D. Lorenz, S.E. McLain, J. Chem. Phys. 144, 225101 (2016).
5 R. J. Gillams, J. V. Busto, S. Busch, C. D. Lorenz, S. E. McLain, J. Phys. Chem. B 119, 128-139 (2015

Molecules, cells and industrial biotechnology
Area of Biology
Chemical Biology
Techniques & Approaches
ChemistrySimulation / Modelling