Sphingolipid Polar Heads: Hydrogen Bonding and Hydration

Maria Eugenia Sanz (primary)
Chemistry
King's College London
Chris Lorenz (secondary)
Physics
King's College London

Abstract

Sphingolipid behaviour is critical in cell regulation and signaling, and it is believed to depend on interactions within and between sphingolipids’ polar heads, and with water. However, there are virtually no investigations of the interactions established by sphingolipids with atomic resolution. This project aims to elucidate these interactions by using a combination of synthetic, spectroscopic and molecular modelling methods.


References

1 Y. A. Hannun, L. M. Obeid, “ Principles of bioactive lipid signalling: lessons from sphingolipids”, Nat Rev. Mol. Cell Biol. 9, 139 (2009)
2 D. Loru, I. Peña, J.L. Alonso, M. E. Sanz, “Intramolecular interactions in the polar headgroup of sphingosine: serinol”, Chem.Comm., 47, 6216 (2016).
3 D. Loru et al, “Conformational Flexibility of Limonene Oxide Studied By Microwave Spectroscopy” ChemPhysChem, 18, 274 (2017), cover.
4 R. J. Gillams, C. D. Lorenz, S.E. McLain, J. Chem. Phys. 144, 225101 (2016).
5 R. J. Gillams, J. V. Busto, S. Busch, C. D. Lorenz, S. E. McLain, J. Phys. Chem. B 119, 128-139 (2015


BBSRC Area
Molecules, cells and industrial biotechnology
Area of Biology
Chemical Biology
Techniques & Approaches
ChemistrySimulation / Modelling