Abstract
GABAA receptors are key components of a normal functioning nervous system by virtue of limiting uncontrolled neuronal excitability. Importantly, the activity of these receptors can be modulated by the binding of (allosteric) ligands and drugs as well as by innate molecules (neurosteroids) that can be used to examine the physiological roles and purpose of these receptors.
Here, we will use structural, computational and electrophysiological methods to examine key binding sites on GABAA receptors taking advantage of their modular nature. The selected sites will involve the neurosteroids and general anaesthetic agents with an aim to designing new receptor isoform specific ligands.
References
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