Abstract
The alternative and canonical NF-kB pathways are essential for the transcription of genes that promote cellular survival and prevent programmed cell death. Both are targets for the Kaposi’s Sarcoma-associated Herpesvirus (KSHV) that renders them constitutively activated, a process that has been directly linked to viral pathogenesis. Using a combination of structural, cell biology and computational methods this project aims to understand the mechanisms by which vFLIP, an essential virally encoded protein, is able to subvert the canonical and alternative pathways. It also seeks to develop potent anti-virals and tool compounds designed to disrupt specific protein-protein interactions that are crucial for viral proliferation and survival.
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