Abstract
The disruption of circadian rhythmicity, such as, for example, exposure to bright light at non-circadian times, causes sleep disruption and has a negative impact on mood and cognition. In this project, we will use a mouse model of exposure to aberrant light conditions that results in sleep disruption and behavioural deficits to ask new questions about the mechanisms underlying these phenomena. We will first map the network of brain regions affected by chronic aberrant light exposure using magnetic resonance imaging (MRI) and then map at the microscale the circuitry eliciting these structural and behavioural responses.
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