Abstract
Epigenetic changes, and specifically, alterations to the DNA methylome, are believed to play an important role in the earliest stages of cancer development. Measuring DNA methylation changes in relevant tissues may thus be informative of cancer risk. This PhD project will use a novel system-epigenomic approach to construct cancer risk prediction models for women specific cancers. It will draw on extensive knowledge of epigenomics, stem-cell biology and cancer, and will use advanced methods from statistics, machine learning and physics to integrate multi-dimensional omic datasets. Corresponding data is already available and data generation will be ongoing throughout the duration of the project via our European partners.
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