Abstract
It is often assumed that DNA exists only as the iconic Watson-Crick “twisted ladder” double helix; but it can actually adopt many different types of structures. These “alternative” structures may play a role in gene expression [whether genes are switched on or off] and also in the development and progression of genetic diseases such as cancer and diabetes. Targeting these alternative DNA structures could allow for specific therapeutics for disease. This project involves developing new compounds to target i-motif DNA structures for use as tools to learn how DNA structures affect genes and to create leads for pre-clinical development.
References
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