Abstract
Hyperthermia has been recently identified as a method to treat tumors. In Thanou’ lab we develop focused ultrasound (FUSH) hyperthermia protocols for disease treatments in combination with tailor made thermosensitive drug carriers. In Thanh’s lab research showed that iron oxide nanoparticles in combination with magnetic field hyperthermia could show great potential on treating solid tumors such as glioblastoma. Magnetic Field Hyperthermia (MFH) has been identified as a possible cancer stem cell killer and as a result this strategy has rapidly moved to clinical trials. Here we propose to investigate the effects of two different methods of applied hyperthermia, focused ultrasound and magnetic field, on cell function and proliferation in vitro and in vivo.
References
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Thermosensitive, Near-Infrared-Labeled Nanoparticles for Topotecan Delivery to Tumors Rosca, E. V., Wright, M., Gonitel, R., Gedroyc, W., Miller, A. D. & Thanou, M. May 2015 In : Molecular Pharmaceutics. 12, 5, p. 1335-1346
Focused ultrasound induced hyperthermia accelerates and increases the uptake of anti-HER-2 antibodies in a xenograft model Centelles, M. N., Wright, M., Gedroyc, W. & Thanou, M. 1 Dec 2016 In : Pharmacological Research. 114, p. 144-151
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