The effect of hyperthermia on tissue permeality and viability in vitro and in vivo

Dr M Thanou (primary)
Cancer and Pharmaceutical Sciences
KCL
Nguyen Thanh (secondary)
Biophysics Group, Physics and Astronomy
UCL

Abstract

Hyperthermia has been recently identified as a method to treat tumors. In Thanou’ lab we develop focused ultrasound (FUSH) hyperthermia protocols for disease treatments in combination with tailor made thermosensitive drug carriers. In Thanh’s lab research showed that iron oxide nanoparticles in combination with magnetic field hyperthermia could show great potential on treating solid tumors such as glioblastoma. Magnetic Field Hyperthermia (MFH) has been identified as a possible cancer stem cell killer and as a result this strategy has rapidly moved to clinical trials. Here we propose to investigate the effects of two different methods of applied hyperthermia, focused ultrasound and magnetic field, on cell function and proliferation in vitro and in vivo.


References

M.N. Centelles, M. Wright, P.W. So, M. Amrahli, X.Y. Xu, J. Stebbing, A.D. Miller, W. Gedroyc, M. Thanou. Image-guided thermosensitive liposomes for focused ultrasound drug delivery: Using NIRF-labelled lipids and topotecan to visualise the effects of hyperthermia in tumours, J Control Release, 280 (2018) 87-98.

Thermosensitive, Near-Infrared-Labeled Nanoparticles for Topotecan Delivery to Tumors Rosca, E. V., Wright, M., Gonitel, R., Gedroyc, W., Miller, A. D. & Thanou, M. May 2015 In : Molecular Pharmaceutics. 12, 5, p. 1335-1346

Focused ultrasound induced hyperthermia accelerates and increases the uptake of anti-HER-2 antibodies in a xenograft model Centelles, M. N., Wright, M., Gedroyc, W. & Thanou, M. 1 Dec 2016 In : Pharmacological Research. 114, p. 144-151

A. Hervault, M. Lim, C. Boyer, A. Dunn, D. Mott, S. Maenosono and N. T. K. Thanh (2016) Doxorubicin loaded dual pH- and thermo-responsive magnetic nanocarrier for combined magnetic hyperthermia and targeted controlled drug delivery applications. Nanoscale. DOI: 10.1039/c5nr07773g. Cover Page.

C. Blanco-Andujar, P. Southern, D. Ortega, S.A. Nesbitt, Q.A., Pankhurst and Thanh, N. T. K. (2016) Real -time tracking of delayed-onset cellular apoptosis induce d by intracellular magnetic hyperthermia. Nanomedicine. 11: 121-136.

Blanco-Andujar, C., Southern, P., Ortega, D., Nesbitt, S.A., Pankhurst, Q.A., Thanh, N.T.K. (2015) High performance multi-core iron oxide nanoparticles for magnetic hyperthermia: microwave synthesis, and the role of core-to-core interactions. Nanoscale. 7: 1768-1775


BBSRC Area
Molecules, cells and industrial biotechnology
Area of Biology
BiotechnologyCell Biology
Techniques & Approaches
BiochemistryBiophysicsChemistryEngineeringImage ProcessingMicroscopy / Electrophysiology