Mitochondria play a role in many important biological processes, facilitated by the transcription of mitochondrial DNA to produce key energy-generating components. Mitochondria are particularly important in high-energy tissues such as the brain, and evidence suggests a major role for mitochondrial dysfunction in neurological disorders. Despite this, it is not understood why the consequences of mitochondrial dysfunction vary in different tissue and cell types. This project will integrate computational analysis of complex single-cell transcriptome data with functional work in cutting-edge iPSC modelling systems to answer a key question: Are aspects of mitochondrial biology specific to certain cell types of the brain?
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