Abstract
It is unclear how the genetic architecture of complex traits differs across populations. Our aims are to determine
(1) how genetic variants affecting a trait differ across populations,
(2) whether genes play a similar role relative to environment, and
(3) if selection has affected these factors.
Using ~300,000 samples with non-European ancestry, the student will characterise the genetics of mental health and biomarker traits and link them to population genetic forces via simulation.
This work will advance our understanding of the basic principles of genetic architecture, and may yield new biological insights pertinent to specific population groups.
References
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