The genomic evolution of primate craniofacial anatomy

Aida Gomez-Robles (primary)
GEE
UCL
Aida Andres (secondary)
GEE
UCL

Abstract

In primates, craniofacial variation provides fundamental cues for individual and species identification. Several genome-wide studies have identified variants that influence facial morphology in humans, including some variants with large effects. Beyond identifying variants that contribute to craniofacial diversity, these studies point to the genes that are responsible for different aspects of face morphology. Drawing from those studies, we will investigate the evolution of genes involved in craniofacial phenotypic variation in humans and other primates. This study will test whether face heterogeneity across individuals is adaptive, and whether species-specific craniofacial configurations are driven by natural selection.


References

Sheehan MJ, Nachman MW. Morphological and population genomic evidence that human faces have evolved to signal individual identity. Nat Commun.5:4800 (2014).

Cagan A, Theunert C, Laayouni H, Santpere G, Pybus M, Casals F, Prüfer K, Navarro A, Marques-Bonet T, Bertranpetit J, Andrés AM. Natural selection in the great apes. Molecular Biology and Evolution, 33:268-283 (2016).

Gómez-Robles A, Smaers JB, Holloway RL, Polly PD, Wood BA. Brain enlargement and dental reduction were not linked in hominin evolution. PNAS 114:468-473 (2017).

Smaers JB, Gómez-Robles A, Parks AN, Sherwood CC. Exceptional evolutionary expansion of prefrontal cortex in great apes and humans. Current Biology 27, 714-720 (2017)

Key FM, Abdud-Aziz M, Peter B, d’Amatto M, Dennis M, Schmidt J, Andrés AM. Human local adaptation of the TRPM8 cold receptor along a latitudinal cline. PLoS Genetics 14: e1007298 (2018).

Claes P, Roosenboom J, White JD, Swigut T, Sero D, Li J, Lee MK, Zaidi A, Mattern BC, Liebowitz C, Pearson L, González T, Leslie EJ, Carlson JC, Orlova E, Suetens P, Vandermeulen D, Feingold E, Marazita ML, Shaffer JR, Wysocka J, Shriver MD, Weinberg SM. Genome-wide mapping of global-to-local genetic effects on human facial shape. Nature Genetics 50:414-423 (2018).

Crouch DJM, Winney B, Koppen WP, Christmas WJ, Hutnik K, Day T, Meena D, Boumertit A, Hysi P, Nessa A, Spector TD, Kittler J, Bodmer WF. Genetics of the human face: Identification of large-effect single gene variants. PNAS 115:E676-E685 (2018).


BBSRC Area
Genes, development and STEM* approaches to biology
Area of Biology
EvolutionGenetics
Techniques & Approaches
BioinformaticsGeneticsMathematics / Statistics