The heart of the bacterial secretion machine

Richard Pickersgill (primary)
School of Biological and Chemical Sciences
Queen Mary University of London
Vidya Darbari (secondary)
School of Biological and Chemical Sciences
Queen Mary University of London

Abstract

We are making unprecedented advances in understanding bacterial secretion by combining a range of disruptive technologies including: transmission electron microscopy, native mass-spectroscopy and in-cell engineering to understand how the type II secretion machine works. This work will help us to fight bacterial infection.


References

For a recent review see:

Gu S, Vladimir VE, Shaw R et al.(2017). The role of intrinsic disorder and dynamics in the assembly and function of the type II secretion system. BBA – Proteins and Proteomics
10.1016/j.bbapap.2017.07.006


BBSRC Area
Molecules, cells and industrial biotechnologyPlants, microbes, food and sustainability
Area of Biology
MicrobiologyStructural Biology
Techniques & Approaches
BiochemistryImage ProcessingMicroscopy / ElectrophysiologyMolecular BiologySimulation / Modelling