The impact of apicomplexan’s MEP pathway on gene regulation and behaviour of the host

Dr. S. Noushin Emami (primary)
University of Greenwich
Prof. Damer Blake (secondary)
Pathobiology & Population Sciences


Our aim is to investigate the role of E-4-hydroxy-3methyl-but-2-enyl-pyrophosphate (HMBPP) as putative feeding stimulant attractant in Toxoplasma infected-mice. Apicomplexan protozoa use the MEP pathway that includes HMBPP while eukaryotes use the mevalonate (MVA) pathway for isoprenoids. Since Toxoplasma infection contributes to disease conditions in two hosts, the balance between genetical and behavioural alteration will be investigated. Toxoplasma infected-mice will be analysed in a spatial and temporal transcriptome (High-density spatial transcriptomics arrays for in situ tissue profiling). Finally, the mice will be exposed to parasite blend (parasite volatile organic compounds [VOC]) and the effects on behaviour, and appetite will be followed.



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Animal disease, health and welfareGenes, development and STEM* approaches to biologyMolecules, cells and industrial biotechnology
Area of Biology
BiotechnologyCell BiologyChemical BiologyNeurobiologyPhysiology
Techniques & Approaches
BiochemistryBioinformaticsChemistryGeneticsMathematics / StatisticsMolecular BiologySimulation / Modelling