The influence of hippocampal mechanisms on visual memory

Isabelle Mareschal (primary)
Psychology
QMUL
Caswell Barry (secondary)
Department of Cell and Developmental Biology
UCL

Abstract

Perceptual learning is an important form of memory in which our ability to distinguish visual forms improves with experience, and is usually thought to reflect plasticity in the visual cortex. Sleep, known to be important in hippocampal memories, has recently been suggested to be important in perceptual learning, implicating the hippocampus as well as the cortex. This projects aims to test the hypothesis that hippocampal activity contributes to visual cortical plasticity and perceptual learning, by studying the influence of sleep on perceptual learning with visual psychophysical measurements in humans, and electrophysiological measurements in rodents.


References

1. Dosher B and Lu Z (2017). Visual perceptual learning and models. Annu Rev Vis Sci. 3: 343-63.

2. Baeck A, Rentmeesters N, Holtackers S, Op de Beeck HP (2014). The effect of sleep in perceptual learning with complex objects. Vision Res. 99: 180-5.

3. Guggenmos M, Rothkirch M, Obermayer K, Haynes JD, Sterzer P (2015). A hippocampal signature of perceptual learning in object recognition. J Cogn Neurosci. 27: 787-97.

4. Larcombe SJ, Kennard C, Bridge H (2018). Increase in MST activity correlates with visual motion learning: a functional MRI study of perceptual learning. Hum Brain Mapp. 39: 145-156.


BBSRC Area
Animal disease, health and welfare
Area of Biology
NeurobiologyPhysiology
Techniques & Approaches
Image ProcessingMathematics / StatisticsMicroscopy / ElectrophysiologySimulation / Modelling