The maturation of the sensory-emotional pain network in the developing brain

Maria (primary)
Neuroscience, Physiology and Pharmacology
UCL
Professor Sofia Olhede (secondary)
Statistical Science
UCL

Abstract

Pain processing is underpinned by the activation of a widespread network of brain areas, which together are responsible for the encoding of the sensory-discriminative and cognitive-emotional qualities of the pain experience. Many of these structures and the connections between them develop in early life. This is a translational project focused on exploring the functional maturation of these connections forming that integrated cortical system that allows us to experience pain. The student will be gaining an interdisciplinary training in human and animal neurophysiology, statistical modelling and time series analysis.


References

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6. Chang, P., Fabrizi, L., Olhede, S. & Fitzgerald, M. The Development of Nociceptive Network Activity in the Somatosensory Cortex of Freely Moving Rat Pups. Cereb. Cortex N. Y. N 1991 26, 4513–4523 (2016).


BBSRC Area
Animal disease, health and welfare
Area of Biology
DevelopmentPhysiology
Techniques & Approaches
Mathematics / StatisticsMicroscopy / ElectrophysiologySimulation / Modelling