Abstract
Malaria, caused by single-cell parasites of the genus Plasmodium, kills over 400,000 people each year. Despite intensive research, there remain many gaps in our understanding of malaria parasite biology. Our group focuses on understanding how signalling by a set of small molecules called cyclic nucleotides controls progression of the parasite life cycle, with the aim of developing new types of antimalarial drugs targeting this signalling pathway [1]. This project will use conditional mutagenesis combined with biochemical and cell biological approaches to dissect and further our understanding of the fascinating biology underpinning the complex life cycle of this important pathogen.
References
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