The role of extracellular vesicles in regulating blood vessel calcification

Isabel Orriss (primary)
Comparative Biomedical Sciences
Royal Veterinary College
Chantal Chenu (secondary)
Comparative Biomedical Sciences
Royal Veterinary College

Abstract

Vascular calcification (VC) is the deposition of calcium phosphate mineral, usually as hydroxyapatite, in the arteries.  Despite being a common consequence of ageing, the cellular mechanisms underpinning VC are poorly understood. Extracellular vesicles (EVs) are small membrane-bound particles released from cells which contain numerous signalling molecules (including the calcification inhibitor, ATP).  Recent work has suggested EVs may play a role in VC.  This studentship will investigate whether the systemic changes that can occur during ageing (e.g. altered blood glucose, calcium or phosphate levels) modulate EV composition and release thereby contributing to the development of VC.


References

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5 Orriss IR (2015).  The role of purinergic signalling in the musculoskeletal system.  Auton Neurosci 191:124-134

BBSRC Area
Animal disease, health and welfare
Area of Biology
AgeingCell Biology
Techniques & Approaches
BiochemistryBioinformaticsImage ProcessingMicroscopy / ElectrophysiologyMolecular Biology