Abstract
Metabolism is essential to sustain a wide range of fundamental cellular functions. However, it is largely unknown how the extracellular environment contributes to the regulation of cellular metabolism. The PhD project will investigate the hypothesis that a pathway links obesity-related inflammation to cellular metabolism in parenchymal cells in breast secretory cells. We will test this pathway by applying metabolomics, molecular biology, imaging and computational approaches in cellular models and by analysing existing gene expression and metabolomic data in obesity and inflammation driven alterations in breast tissue.
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