Abstract
Proper distribution of proteins and organelles is essential for maintaining neuronal structure and function. It has been suggested that reduced transport in axons of neurons contributes to the broader decline of cellular homeostasis that occurs during ageing. Although upregulation of transport appears to be beneficial in ageing neurons, it is still unknown how modulation of this process mechanistically affects ageing phenotypes, for instance the appearance of protein aggregates. The successful candidate will combine new methods in Drosophila melanogaster with the use of stem cell technology to study the link between axonal transport and protein aggregation in vivo and in vitro.
References
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