The role of the Foxa pioneer transcription factor family in T-cell development and TCR repertoire selection

Tessa Crompton (primary)
GOS Institute of Child Health
Benny Chain (secondary)
Department of Computer science and Division of Infection and Immunity


Pioneer transcription factors bind silent condensed chromatin early in a developmental programme prior to target gene activation, either to open up local chromatin, imparting competence to other transcriptional activators to initiate a developmental lineage, or to directly facilitate other factors binding to nucleosomal DNA; and they may also demethylate tissue-specific regions of DNA, to generate stable lineage-specific DNA methylation patterns to enhance gene expression. This project will investigate the mechanisms of the Foxa family of transcription factors in their regulation of T-cell development and investigate how they influence TCR repertoire diversity.


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Molecules, cells and industrial biotechnology
Area of Biology
Techniques & Approaches
BioinformaticsGeneticsMathematics / StatisticsMolecular Biology