Abstract
Bacterial biofilm-mediated infections are a serious threat to humans, due to their extreme physical resilience and their reduced susceptibility to available antibacterials. Therefore, there is an urgent need to study the properties of biofilms and find new classes of molecules able to disrupt biofilms and treat infection directly or for use as adjunctive agents for existing treatments. This project aims to develop state of the art low-cost microfluidic systems to investigate degradation of clinically challenging bacterial biofilms via a metagenomic library screening approach, in an effort to reduce the impact of biofilm-mediated nosocomial infections.
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