Abstract
The ability of therapeutic cells to regenerate damaged tissue is well established, and a new generation of cell therapies are now reaching the clinic. In order to develop this field further it is essential to understand how cells exert their therapeutic effects. There is mounting evidence that many bioactive compounds underpinning regeneration are clustered in cell-secreted bodies known as extracellular vesicles (EVs). This presents the exciting possibility that application of EVs alone (without implanting cells) can be used in regenerative treatments. This project will use a multidisciplinary approach to develop advanced EV formulations with potential for use in regenerative medicine.
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