Recent work demonstrates that receptors transmit information not only from the cell surface but also from inside the cells, on endosomes. The aim is to understand how receptor tyrosine kinases (RTK) transmit information inside the cell and why intracellular RTK activity is required for optimal cell behaviour. This project will apply engineering technology for the automatic image analysis, quantification, and modelling of RTK “endosomal signalling” in human cancer cells and tissues, combined to biochemistry and functional assays including cell migration, proliferation and survival. Novel technologies measuring and modelling receptor endosomal signalling will be generated, enhancing basic knowledge of receptor signalling.
Kermorgant S and Parker PJ. Receptor trafficking controls weak signal delivery: a strategy employed by c-Met for STAT3 nuclear accumulation J Cell Biol 18:855-63
Joffre C, Barrow R, Ménard L, Calleja V, Hart IR and Kermorgant S. A direct role for Met endocytosis in tumorigenesis Nature Cell Biology 13:827-37
Barrow-McGee R, Kermorgant S. Met Endosomal Signalling: In the right place, at the right time. Int J Biochem Cell Biol 2014, 49:69-74
Ménard L, Parker PJ, Kermorgant S. Receptor Tyrosine Kinase c-Met controls the cytoskeleton from different endosomes via different pathways. Nature Communications 2014, 5:3907
Barrow-McGee, R. et al. Beta 1-integrin–c-Met cooperation reveals an inside-in survival signalling on autophagy-related endomembranes. Nature Communications 2016, 7:11942