Tracking Cancer Signalling

Stephanie Kermorgant (primary)
Barts Cancer Institute
Paul Fromme (secondary)
Department of Mechanical Engineering


Recent work demonstrates that receptors transmit information not only from the cell surface but also from inside the cells, on endosomes. The aim is to understand how receptor tyrosine kinases (RTK) transmit information inside the cell and why intracellular RTK activity is required for optimal cell behaviour. This project will apply engineering technology for the automatic imaging, quantification, and modelling of RTK “endosomal signalling” in human cancer cells and tissues, combined to biochemistry and functional assays including cell migration, proliferation and survival. Novel technologies measuring and modeling receptor endosomal signalling will be generated, enhancing basic knowledge of receptor signalling.


1) Joffre C, Barrow R, Ménard L, Calleja V, Hart IR and Kermorgant S. A direct role for Met endocytosis in tumorigenesis Nature Cell Biology 2011, 13:827-37
2) Ménard L, Parker PJ, Kermorgant S. Receptor Tyrosine Kinase c-Met controls the cytoskeleton from different endosomes via different pathways. Nature Communications 2014, 5:3907
3) Barrow-McGee, R. et al. Beta 1-integrin–c-Met cooperation reveals an inside-in survival signalling on autophagy-related endomembranes. Nature Communications 2016, 7:11942
4) Barrow-McGee R, Kermorgant S. Met Endosomal Signalling: In the right place, at the right time. Int J Biochem Cell Biol 2014, 49:69-74;
5) Kermorgant S and Parker PJ. Receptor trafficking controls weak signal delivery: a strategy employed by c-Met for STAT3 nuclear accumulation J Cell Biol 2008, 18:855-63

Molecules, cells and industrial biotechnology
Area of Biology
AgeingCell Biology
Techniques & Approaches
BiochemistryEngineeringImage ProcessingMathematics / StatisticsMicroscopy / ElectrophysiologyMolecular BiologySimulation / Modelling