Abstract
In adult tissues, stem cells maintain homeostasis by dividing to give rise to both new stem cells and differentiated cells. One mechanism by which stem cells balance self-renewal and differentiation is through competition between stem cells for space at the supportive micro-environment, or niche: cells which remain in the niche self-renew, while those pushed out differentiate. This project will use new genetic tools and computational tracking methods to visualise this process in an intact stem cell niche and understand how stem cells interact with each other and the niche to determine what fate to adopt.
References
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