Transmission networks of novel zoonotic hybrid schistosomes in West Africa.

Joanne P Webster (primary)
Pathobiology and Population Sciences (PPS)
Royal Veterinary College
Alan Wilson (secondary)
Comparative Biomedical Sciences
Royal Veterinary College

Abstract

The major aim of this trans-disciplinary project is to elucidate the complex dynamics of novel zoonotic hybrid schistosomiasis transmission in West Africa using cutting edge genetics, genomics, GPS and UAV video tracking of host and social network modelling.  We predict that recent and on-going anthropogenic changes, combined with shifts in human demography and animal husbandry, will lead to increased opportunities for inter-specific parasite interactions and pairings between human and livestock schistosome species resulting in introgressions and the establishment of novel zoonotic hybrids.   This in turn will change the host range, force of transmission level, and efficacy of disease control programmes.


References

  1. Webster, J.P., Borlase, A.M. & Rudge, J.W. (2017). Who acquires infection from whom, and how? – disentangling multi-host and multi-mode transmission dynamics in the ‘elimination’ era. Philosophical Transactions of the Royal Society London Series B (Biological Sciences). 372 (1719) 20160091; doi:10.1098/rstb.2016.0091 IF 7.055
  2. Leger, E. Garba, A., Hamidou, A.A., Webster, B.L., Pennance, T., Rollinson, D. & Webster, J.P. (2016). Introgressed animal schistosomes Schistosoma curassoni and S. bovis naturally infecting humans. Emerging Infectious Diseases. 22 (12) 2212-2214 DOI: http://dx.doi.org/10.3201/eid2212.160644 IF 6.99
  3. King, K.C.*, Stelkens, R.B.*, Webster, J.P.*, Smith, D.F. & Brockhurst, M.A. (2015). Hybridization in parasites: consequences for adaptive evolution, pathogenesis and public health in a changing world. PLoS Pathogens. 11(9): e1005098, 1-12. doi:10.1371/journal.ppat.1005098 IF 8.06 * Joint first author
  4. Rudge, J.W., Webster, J.P., Lu, D-B., Wang, T-P., Fang, G-R., Basanez, M-G. (2013). Identifying host species driving transmission of schistosomiasis japonica, a multi-host parasite system, in China. PNAS – Proceedings of the National Academy of Sciences of the United States of America. 110. 11457-11462. (Direct submission). PMC3710859 IF 9.737
  5. Haddadi H, King A, Wills A, Fay D, Lowe J, Morton J, Hailes S, & Wilson A. (2011) Determining association networks in social animals: choosing spatial-temporal criteria and sampling rates. Behavioural Ecology and Sociobiology, 65: 8: 1659-1668. IF 2.752

BBSRC Area
Animal disease, health and welfare
Area of Biology
EvolutionGenetics
Techniques & Approaches
BioinformaticsChemistryEngineeringGeneticsImage ProcessingMathematics / StatisticsMicroscopy / ElectrophysiologyMolecular BiologySimulation / Modelling