Abstract
The collection of epitopes this is presented on cell surfaces drives the CD8+ T cell response and determines how the healthy status of each individual is patrolled. Recently, many tools and strategies have been developed for predicting which set of peptide fragments constitute conventional epitopes that can be recognised by CD8+ T cells. The aim of this project is to develop computational strategies for predicting and identify unconventional antigenic peptides, and to validate them in various in vitro and in cellulo systems. This project is highly interdisciplinary, involving substantial elements of computational modelling, immuno-biochemistry and wet-lab work.
References
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