Antibiotic resistance is one of the biggest public health challenges of our time. With a limited number of new drugs being developed, it is important to identify ways to maximise the lifetime of the existing drugs. The use of combinatory drug regimens has been proposed to be an attractive solution to the treatment of antibiotic resistant infections. This project will investigate the molecular and cellular mechanisms of synergistic drug combinations using a combination of microbiology, omics and bioinformatic approaches to characterise the fundamental aspects of combinatory drug treatment that can then guide rational design of future drug combinations.
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3 Federico Fenaroli, James D Robertson, Edoardo Scarpa, Virginia M Gouveia, Claudia Di Guglielmo, Cesare De Pace, Philip M Elks, Alessandro Poma, Dimitrios Evangelopoulos, Julio Ortiz Canseco, Helen M Marriott, David H Dockrell, Simon Foster, Timothy D. McHugh, Stephen A. Renshaw, Josep Samitier Marti, Giuseppe Battaglia, and Loris Rizzello. Polymersomes Eradicating Intracellular Bacteria. ACS Nano Just Accepted Manuscript. DOI: 10.1021/acsnano.0c01870
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5 Chiner-Oms Á, Berney M, Boinett C, González-Candelas F, Young DB, Gagneux S, Jacobs WR, Parkhill J, Cortes T, Comas I. Genome-wide mutational biases fuel transcriptional diversity in the Mycobacterium tuberculosis complex. Nat Commun 2019, 10, 3994