Abstract
Brain function requires multiple types of neurons characterised by distinctive structural, molecular and physiological features. How this diversity emerges from a smaller number of progenitor states is a fascinating biological problem. This project will elucidate gene regulation networks allowing neural stem cells to differentiate into different types of cortical interneurons. It will combine advanced computational analyses of single-cell gene expression data with experimental validation of predicted regulators using cutting-edge in vitro and in vivo approaches. We expect to uncover novel mechanisms underlying nervous system development and devise new stem cell-based protocols for generating specific types of interneurons in vitro.
References
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