Brain function requires multiple types of neurons characterised by distinctive structural, molecular and physiological features. How this diversity emerges from a smaller number of progenitor states is a fascinating biological problem. This project will elucidate gene regulation networks allowing neural stem cells to differentiate into different types of cortical interneurons. It will combine advanced computational analyses of single-cell gene expression data with experimental validation of predicted regulators using cutting-edge in vitro and in vivo approaches. We expect to uncover novel mechanisms underlying nervous system development and devise new stem cell-based protocols for generating specific types of interneurons in vitro.
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2. Mi D, Li Z, Lim L, Li M, Moissidis M, Yang Y, Gao T, Hu TX, Pratt T, Price DJ, Sestan N, and Marín O (2018) Early emergence of cortical interneuron diversity in the mouse embryo. Science 360, 81-85. https://doi.org/10.1126/science.aar6821
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