Understanding structures in the human eye through a cross vertebrate species comparison

Ian Eames (primary)
Mechanical Engineering
University College London
Dominic Wells (secondary)
Comparative Biomedical Sciences
Royal Veterinary College

Abstract

The fundamental mechanisms behind many functional aspects of the eye, such as aqueous flow routes, tear drainage and the supply of energy to different ocular structures, are not well-understood. We propose to characterise and describe these features through comparative anatomy and physiology of the eye among vertebrates. Ocular structures will be compared between species by harnessing the unique collection of tissue samples from the Royal Veterinary College, and specific species adaptations will be identified. Physical or mathematical models will then be developed to simulate the function associated with these structures, and will be used to explain observed differences and common adaptations.


References

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  2. Zouache, M.A., Eames, I., Samsudin, A. Allometry and scaling of the intraocular pressure and aqueous humour flow rate in vertebrate eyes (2016) PLoS ONE, 11 (3), art. no. e0151490,
  3. Zouache, M.A., Eames, I., Luthert, P.J. Blood flow in the choriocapillaris (2015) Journal of Fluid Mechanics, 774, pp. 37-66.
  4. Samsudin, A., Eames, I., Brocchini, S., Khaw, P.T. The Influence of Scleral Flap Thickness, Shape, and Sutures on Intraocular Pressure (IOP) and Aqueous Humor Flow Direction in a Trabeculectomy Model (2016) Journal of Glaucoma, 25 (7),

BBSRC Area
Animal disease, health and welfare
Area of Biology
MicrobiologyStructural Biology
Techniques & Approaches
BiochemistryBiophysicsEngineeringImage ProcessingSimulation / Modelling