Understanding the antimicrobial activity of amyloid peptides

Martin Ulmschneider (primary)
Department of Chemistry
King’s College London
Chris Lorenz (secondary)
Department of Physics
King's College London


Microbial attack on the brain has been suggested as a potential root-cause for dementia, including Alzheimer’s disease (AD), which is now the second leading cause of death in the UK. The defining diagnostic marker of AD is the presence of amyloid-β (Aβ) plaques in the brain. The precise physiological role of these plaques remains unclear, but recent work is suggesting a direct connection to bacterial infiltration of the brain. In this project you will explore the antimicrobial properties of Aβ peptides and determine their mechanisms of activity.


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Molecules, cells and industrial biotechnology
Area of Biology
AgeingChemical Biology
Techniques & Approaches
BiochemistryBiophysicsMathematics / StatisticsMolecular BiologySimulation / Modelling