Abstract
Interferon-induced transmembrane (IFITM) proteins are host cell factors with potent inhibitory activity against numerous pathogenic and zoonotic viruses. IFITMs have been proposed to act by increasing the rigidity of cellular membranes, with IFITM protein localised at sites of virus entry. We will determine how the subcellular targeting and trafficking of IFITMs affect their antiviral functions. IFITMs of different species and site-directed mutants will be systematically analysed using bioinformatic, biochemical and imaging methods for their restriction of various viruses. Mechanistic insights gained will help define how IFITMs could be used therapeutically or prophylactically in human and veterinary medicine against viruses.
References
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