Understanding the neural circuit computation underlaying outcome specific conditioned inhibition.

camilla larsen (primary)
Department of Developmental Neurobiology
King's College London
Martin Meyer (secondary)
MRC centre for developmental disorders
King's college London


All animals, including humans, make continuous choices based on past experience, current sensory input and internal state. We use olfaction as a paradigm to study how experience (learning) and present stimuli (odour) direct behaviour in Drosophila larvae. Larvae can learn to associate an odour with a lack of reward. This is termed outcome specific conditioned inhibition (OSCI) and is an important learning mechanism that allows animals to adopt new approaches in changing environmental conditions. The aim of this project is to understand the neural basis of OSCI.


The impact of odor-reward memory on chemotaxis in larval Drosophila.
Schleyer M, Reid SF, Pamir E, Saumweber T, Paisios E, Davies A, Gerber B, Louis M.
Learn Mem. 2015 Apr 17;22(5):267-77. doi: 10.1101/lm.037978.114. Print 2015 May.

Connectomics and function of a memory network: the mushroom body of larval Drosophila.
Thum AS, Gerber B.
Curr Opin Neurobiol. 2019 Feb;54:146-154. doi: 10.1016/j.conb.2018.10.007. Epub 2018 Oct 24. Review.

The complete connectome of a learning and memory centre in an insect brain.
Eichler K, Li F, Litwin-Kumar A, Park Y, Andrade I, Schneider-Mizell CM, Saumweber T, Huser A, Eschbach C, Gerber B, Fetter RD, Truman JW, Priebe CE, Abbott LF, Thum AS, Zlatic M, Cardona A.

Animal disease, health and welfare
Area of Biology
Techniques & Approaches
GeneticsMathematics / StatisticsMicroscopy / ElectrophysiologySimulation / Modelling