Abstract
Osteoarthritis (OA) is a degenerative joint disease, typified by a degradation of cartilage and changes in the subchondral bone, resulting in pain, stiffness and reduced mobility. However, the precise interaction between the remodeling of subchondral bone and the cartilage degeneration in OA patients remains unclear. To develop an effective treatment for OA, it is important to understand how the physical environment provided by the subchondral bone affects the overlying cartilage in the osteoarthritic joints. In this project, we will examine the remodelling of the subchondral bone in the OA joints and examine the regenerative potential of MSCs at difference stage of OA.
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