Abstract
Mitophagy is crucial to maintain a pool of healthy mitochondria for optimal cellular energy production and to avoid the toxic accumulation of heavily damaged mitochondria. The HPF laboratory has performed large-scale metabolomics and transcriptomics to interrogate upstream signaling pathways regulating mitophagy, and the cysteine oxidation pathway has emerged as key in the process. Our proposal builds upon this data and capitalises on the strengths of the HPF lab in mitochondrial biology research together with the JH lab’s expertise in the chemistry of cysteine oxidation to deepen our understanding of the molecular mechanisms of mitophagy.
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