Organisms have evolved to optimally exploit their environment and maximise their survival an reproduction within the constraints of the resources available. This project aims to improve our understanding of the genetics of metabolic and physiological responses to diet, in order to gain insights into their capacity to evolve, he genetic constraints limiting their adaptation and how these can impact organismal health and performance. We do so using the fruit fly as a model, which shares many of the conserved regulatory mechanisms with mammals [including humans] but allows us to use powerful experimental approaches and exploit sophisticated genetic resources.
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Partridge L, Alic N, Bjedov I, Piper MDW  Ageing in Drosophila: The role of insulin/Igf and TOR signaling network. Exp Gerontol 46:376-381.
Mackay TF, Richards S, Stone EA, Barbadilla A, Ayroles JF, Zhu D, et al.  The Drosophila melanogaster Genetic Reference Panel. Nature 482:173-178.