Abstract
Protein aggregation plays a central role in a wide range of fields, from biotechnology, to human health and physiology, but the process is not understood at the molecular level and the cellular consequences are often confusing. Elucidating the features which govern protein aggregation is a central problem in structural biology and cell biology. Using the pancreatic hormone amylin, as a model system, the PhD student will conduct interdisciplinary research involving state of the art mass spectrometry assays together with biochemical and cell biology measurements to quantitatively relate specific conformational features of the protein to its tendency to aggregate.
References
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