Simultaneous and recursive relationships exist in many biology system. For example, animal movement is dictated by joint and bone structure, and the way animals move can also affect how the bone and joint mature and/or degenerate with ageing. However, there is limited knowledge regarding the causal relationships among gait, bone shape and joint structure changes. Understanding the interconnected causal networks among these features may allow earlier diagnosis of major joint diseases. The aim of the project is to elucidate the different connectivity and causality structures among osteoarthritic features, and to evaluate the likelihood of mitigate or alter their progression experimentally.
Jadoon, M. M., Zhang, Q., Haq, I. U., Butt, S., & Jadoon, A. (2017). Three-class mammogram classification based on descriptive CNN features. BioMed research international, 2017. https://doi.org/10.1155/2017/3640901
Javaheri, B., Razi, H., Piles, M., de Souza, R., Chang, Y.M., Maric-Mur, I., Hopkinson, M., Lee, P.D., Pitsillides, A.A. (2018) Sexually dimorphic tibia shape is linked to natural osteoarthritis in STR/Ort mice. Osteoarthritis and Cartilage (in press). https://doi.org/10.1016/j.joca.2018.03.008
Javaheri, B., Poulet, B., Aljazzar, A., de Souza, R., Piles, M., Hopkinson, M., Shervill, E., Pollard, A., Chan, B., Chang, Y.M., Orriss, I.R., Lee, P.D., Pitsillides, A.A. (2017). Stable sulforaphane protects against gait anomalies and modifies bone microarchitecture in the spontaneous STR/Ort model of osteoarthritis. Bone Vol 103, pp 308-317
Elwert, F. (2013) Graphical Causal Models. DOI 10.1007/978-94-007-6094-3_13
Poulet, B., de Souza, R., Knights, C.B., Gentry, C., Wilson, A.M., Bevan, S., Chang, Y.M., Pitsillides, A.A. (2014) Modifications of gait as predictors of natural osteoarthritis progression in STR/Ort mice. Arthritis & Rheumatology Vol. 66, No. 7, pp 1832–1842
Xu, Z., & Zhang, Q. (2018). Multi-scale context-aware networks for quantitative assessment of colorectal liver metastases. 2018 IEEE EMBS International Conference on Biomedical & Health Informatics (BHI), pp. 369-372