Lameness is a debilitating and painful condition, compromising considerably animal and human welfare. In dairy-cattle, the main cause of lameness is claw horn disruption lesions (CHDL) which affect one third of the animals. Initial genetic studies showed that the disease is heritable. Further “-omics” studies could provide new insights to mechanisms driving disease perturbation and facilitate disease control through breeding-programmes, novel DNA-tests and novel drug- and vaccine-target discovery. We will integrate genomics/transcriptomics/proteomics and applied cutting edge machine-learning and systems-biology approaches to investigate the genetic architecture and underlying molecular mechanisms of CHDL in order to develop new tools to control the disease.
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