Using protein structure analysis to model the interactions of synaptic adhesion molecules and their biological function

Robert Hindges (primary)
Centre for Developmental Neurobiology
King's College London
Maria (Sasi) Conte (secondary)
Randall Division of Cell and Molecular Biophysics
King's College London

Abstract

Teneurins belong to a family of synaptic adhesion molecules widely expressed in the nervous system. These transmembrane proteins form cis-dimers and data suggest they interact across the synapse either homo- or heterophilically. Our previous research has shown that individual teneurins are responsible for the establishment of functionally distinct neural circuits. However, the molecular basis how to mediate synaptic specificity is unknown. Although there are predictions regarding the protein domains for cis- and trans-interactions, no detailed protein structure has yet been solved.  This project aims at identifying the molecular teneurin structure to model their protein interactions and thus explain biological functionality.


References

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BBSRC Area
Molecules, cells and industrial biotechnology
Area of Biology
NeurobiologyStructural Biology
Techniques & Approaches
BiochemistryBioinformaticsBiophysicsImage ProcessingMicroscopy / ElectrophysiologyMolecular BiologySimulation / Modelling