Knowing the direction of transmission between two infected individuals provides a powerful insight into both the epidemiology and evolution of infectious disease. Recent methods have leveraged pathogen sequence data to identify the transmitting and recipient individual for multiple pathogens including viruses and bacteria. However, these methods vary in their accuracy across studies and across pathogens. To improve the accuracy of these methods we need to identify when they fail. Using a multidisciplinary approach, this project will work at the cutting edge of phylogenetics to improve current methods to identify the direction of transmission.
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