Bone defects often require substantial donor bone tissue and represent a burden for patients and healthcare systems. Stem cell-based tissue engineering holds a great promise for improving human health by using stem cells to repair damaged tissues in the body or replace diseased tissue with a healthy tissue. The proposed project will combine the expertise in stem cell biology and tissue engineering (Habib Lab), protein chemistry (Muller Lab) and material engineering (Gentleman lab) to generate a 3D human osteogenic tissue in vitro, characterise its function and probe its potential to repair severe bone defects in old animals.
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Lowndes M, Junyent S and Habib SJ (2017) Constructing cellular niche properties by localized presentation of Wnt proteins on synthetic surfaces. Nature Protocols 12(7):1498-1512
Lowndes M, Rotherham M, Price JC, El Haj AJ, Habib SJ (2016) Immobilized WNT proteins act as a stem cell niche for tissue engineering. Stem Cell Reports. 12;7(1):126-37
ILC1 drive intestinal epithelial and matrix remodelling Jowett, G. M., et al and Gentelman E., NATURE MATERIALS. 20, 2, p. 250-259 10 p.
Semisynthetic ‘designer’ p53 sheds light on a phosphorylation-acetylation relay. Margiola S, Gerecht K, Müller MM. Chem Sci 2021 in press. https://doi.org/10.1039/D1SC00396H